Whirler Mutant Hair Cells Have Less Severe Pathology than Shaker 2 or Double Mutants
نویسندگان
چکیده
منابع مشابه
Hair cells in the inner ear of the pirouette and shaker 2 mutant mice.
The shaker 2 (sh2) and pirouette (pi) mouse mutants display severe inner ear dysfunction that involves both auditory and vestibular manifestation. Pathology of the stereocilia of hair cells has been found in both mutants. This study was designed to further our knowledge of the pathological characteristics of the inner ear sensory epithelia in both the sh2 and pi strains. Measurements of auditor...
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Stereocilia, finger-like projections forming the hair bundle on the apical surface of sensory hair cells in the cochlea, are responsible for mechanosensation and ultimately the perception of sound. The actin cytoskeleton of the stereocilia contains hundreds of tightly cross-linked parallel actin filaments in a paracrystalline array and it is vital for their function. Although several genes have...
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ژورنال
عنوان ژورنال: Journal of the Association for Research in Otolaryngology
سال: 2007
ISSN: 1525-3961,1438-7573
DOI: 10.1007/s10162-007-0083-x